Lactase Deficiency and Colonic Mucosal Eosinophilia (P19-014-19)
نویسندگان
چکیده
منابع مشابه
Prevalence of lactase deficiency in British adults.
The prevalence of lactase deficiency in British adults is unknown. Examination of the distribution of lactase activities in single and multiple biopsies of jejunum indicated that 0.8 U/g wet weight was a suitable cut-off point to separate lactase deficient patients from others. One hundred and fifty white British adults were selected, none of whom had significant intestinal disease and all of w...
متن کاملThe biosynthetic basis of adult lactase deficiency.
The intestinal brush-border enzyme lactase splits lactose into its component monosaccharides, glucose and galactose. Relative deficiency of the enzyme during adulthood is a common condition worldwide and is frequently associated with symptoms of lactose intolerance. We studied the synthesis and processing of lactase in normal and adult hypolactasic subjects using human intestinal explants in or...
متن کاملFour novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD)
BACKGROUND Congenital lactase deficiency (CLD) is a severe gastrointestinal disorder of newborns. The diagnosis is challenging and based on clinical symptoms and low lactase activity in intestinal biopsy specimens. The disease is enriched in Finland but is also present in other parts of the world. Mutations encoding the lactase (LCT) gene have recently been shown to underlie CLD. The purpose of...
متن کاملEffect of ageing on colonic mucosal regeneration.
The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the epithelium. On the one hand, age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation, which results in epithelial damage. On the other hand, the alter...
متن کاملAutoradiographicCytokineticsof Colonic Mucosal Hyperplasia in Mice1
The cytokinetics of a naturally occurring hyperplastic disease of the colon in mice were determined by autora diography and compared to kinetic changes seen by others in nonneoplastic and neoplastic colonic disease. Cell cycle parameters were determined using the fraction-labeled mi tosis method. Labeling index, labeling pattern, and migra tion rates were also evaluated. During colonic hyperpla...
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ژورنال
عنوان ژورنال: Current Developments in Nutrition
سال: 2019
ISSN: 2475-2991
DOI: 10.1093/cdn/nzz049.p19-014-19